Category: NSAID Analgesic + Proteolytic Enzyme (Anti-Edema) • Catalog ID: ZERODOL-SP • Reviewed by MediMatch Clinical Pharmacology Review Board
Zerodol-SP Tablet — Aceclofenac (INN) 100mg + Paracetamol (INN) / Acetaminophen (USAN) 325mg + Serratiopeptidase 15mg
Evidence-based clinical monograph for Zerodol-SP Tablet, formulated with active pharmaceutical ingredient Aceclofenac (INN) 100mg + Paracetamol (INN) / Acetaminophen (USAN) 325mg + Serratiopeptidase 15mg and manufactured by Ipca Laboratories Ltd. Includes FDA/EMA/WHO international nomenclature cross-walk, 6-point patient safety matrix, and multi-currency generic reference pricing.
1. Quick Facts & Global Nomenclature Cross-Walk (WHO INN / US FDA USAN / UK BNF)
| Brand Name | Zerodol-SP (Tablet) |
|---|
| Active Salt (WHO INN) | Paracetamol (WHO INN) |
|---|
| U.S. FDA USAN / Orange Book | Acetaminophen (USP / FDA Orange Book) |
|---|
| UK BNF / EMA BAN | Paracetamol (BP / Ph. Eur.) |
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| Global Commercial Brand Equivalents by Region | 🇺🇸 USA/Canada: Tylenol 500mg / FeverAll (Tylenol Extra Strength) • 🇬🇧 UK/Europe: Panadol Advance / Efferalgan • 🇦🇺 Australia: Panadol Optizorb (TGA) • 🇦🇪 UAE/GCC: Panadol / Adol 500mg (MOHAP) • 🇮🇳 India: Zerodol-SP / Crocin / Dolo 650 |
|---|
| Same-Salt Commercial Brand Substitutes | Zerodol-SPAldigesic-SPHifenac-SPSignoflamMovexx-SPFlozen-AA |
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| Dosage Form & Route | Tablet (Oral Systemic Administration) |
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| Manufacturer | Ipca Laboratories Ltd |
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| Branded MRP vs Jan Aushadhi Generic | MRP ₹128.00 vs Jan Aushadhi ₹22.00 • Save ₹106.00 (83% Off) |
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3. Clinical Indications, Mechanism of Action & Pharmacokinetics
Zerodol-SP (Tablet) containing Aceclofenac (INN) 100mg + Paracetamol (INN) / Acetaminophen (USAN) 325mg + Serratiopeptidase 15mg is clinically indicated for the management and treatment of:
- Post-operative swelling & pain: Targeted therapeutic efficacy via NSAID Analgesic + Proteolytic Enzyme (Anti-Edema) pathway modulation.
- Severe joint & knee pain: Targeted therapeutic efficacy via NSAID Analgesic + Proteolytic Enzyme (Anti-Edema) pathway modulation.
- Dental extraction swelling: Targeted therapeutic efficacy via NSAID Analgesic + Proteolytic Enzyme (Anti-Edema) pathway modulation.
- Ligament sprain & sports injury: Targeted therapeutic efficacy via NSAID Analgesic + Proteolytic Enzyme (Anti-Edema) pathway modulation.
- Spondylitis: Targeted therapeutic efficacy via NSAID Analgesic + Proteolytic Enzyme (Anti-Edema) pathway modulation.
Mechanism of Action & Pharmacokinetics: Following administration as a tablet, Aceclofenac (INN) 100mg + Paracetamol (INN) / Acetaminophen (USAN) 325mg + Serratiopeptidase 15mg undergoes calibrated systemic absorption and hepatic/renal clearance in accordance with WHO-GMP, USP, and Indian Pharmacopoeia (IP) dissolution and bioequivalence standards.
4. Standard Dosage Table, Administration & Storage Guidelines
Dosage & Administration Reference Table: Always follow your physician's prescription for Zerodol-SP Tablet (ISMP safety normalized):
| Prescription Sig Code |
Administration Schedule |
Meal & Timing Guidance |
Clinical Patient Group |
| OD (Once Daily) |
1 unit (Tablet) every 24 hours |
Take after food with a full glass of water |
Adults |
| BD / BID (Twice Daily) |
1 unit (Tablet) every 12 hours (Morning & Night) |
Take after food with a full glass of water |
Adults |
| TDS / TID (Thrice Daily) |
1 unit (Tablet) every 8 hours (if prescribed) |
Maintain minimum 6–8 hour spacing |
As directed by registered physician |
Storage & Stability: Store Zerodol-SP (Tablet) in a cool, dry place below 30°C (86°F) away from direct sunlight, heat, and moisture. Keep blister strips sealed until administration and out of reach of children.
8. Frequently Asked Questions (Zerodol-SP Tablet)
Q: What is Zerodol-SP Tablet (Aceclofenac (INN) 100mg + Paracetamol (INN) / Acetaminophen (USAN) 325mg + Serratiopeptidase 15mg) used for?
Zerodol-SP Tablet contains Aceclofenac (INN) 100mg + Paracetamol (INN) / Acetaminophen (USAN) 325mg + Serratiopeptidase 15mg and is manufactured by Ipca Laboratories Ltd. It is primarily indicated for Post-operative swelling & pain, Severe joint & knee pain, Dental extraction swelling, Ligament sprain & sports injury, Spondylitis under the NSAID Analgesic + Proteolytic Enzyme (Anti-Edema) therapeutic class.
Q: Is a generic equivalent or Jan Aushadhi substitute available for Zerodol-SP Tablet?
Yes, bioequivalent generic Aceclofenac (INN) 100mg + Paracetamol (INN) / Acetaminophen (USAN) 325mg + Serratiopeptidase 15mg (Tablet) is available globally ($3.96 USD NADAC / £3.08 UK NHS Tariff) and at PMBJP Jan Aushadhi Kendras in India for ₹22.00 per strip, saving 83% compared to branded MRP ₹128.00.
Q: What is the dosage instruction for Zerodol-SP Tablet?
Common dosage frequencies for Zerodol-SP (Tablet) are OD (once daily), BD/BID (twice daily), or TDS/TID (thrice daily) as prescribed by your physician. Take after food with a full glass of water
Q: Is Zerodol-SP Tablet safe during pregnancy, breastfeeding, or with alcohol?
Pregnancy guidance: SAFE (Considered first-line antipyretic/analgesic across pregnancy trimesters at lowest effective dose for shortest duration (FDA PLLR / TGA Cat A).) Alcohol guidance: AVOID (Strictly avoid chronic or heavy alcohol use due to CYP2E1 induction and heightened acute hepatotoxicity risk (max 4,000 mg/day).)