Category: PPI Antacid + Prokinetic Antiemetic • Catalog ID: PAN-D • Reviewed by MediMatch Clinical Pharmacology Review Board
Pan-D Capsule (Hard Gelatin SR) — Pantoprazole Sodium (INN/USAN) 40mg + Domperidone (INN/BAN) 30mg Sustained Release
Evidence-based clinical monograph for Pan-D Capsule (Hard Gelatin SR), formulated with active pharmaceutical ingredient Pantoprazole Sodium (INN/USAN) 40mg + Domperidone (INN/BAN) 30mg Sustained Release and manufactured by Alkem Laboratories Ltd. Includes FDA/EMA/WHO international nomenclature cross-walk, 6-point patient safety matrix, and multi-currency generic reference pricing.
1. Quick Facts & Global Nomenclature Cross-Walk (WHO INN / US FDA USAN / UK BNF)
| Brand Name | Pan-D (Capsule (Hard Gelatin SR)) |
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| Active Salt (WHO INN) | Pantoprazole Sodium (INN/USAN) 40mg + Domperidone (INN/BAN) 30mg Sustained Release (WHO INN) |
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| U.S. FDA USAN / Orange Book | Pantoprazole Sodium (INN/USAN) 40mg + Domperidone (INN/BAN) 30mg Sustained Release Delayed-Release (USP) |
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| UK BNF / EMA BAN | Pantoprazole Sodium (INN/USAN) 40mg + Domperidone (INN/BAN) 30mg Sustained Release Gastro-Resistant (BP) |
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| Global Commercial Brand Equivalents by Region | 🇺🇸 USA/Canada: Prilosec OTC / Nexium / Protonix (Losec / Nexium 24HR) • 🇬🇧 UK/Europe: Losec / Nexium Control / Pantoloc • 🇦🇺 Australia: Losec / Somac (PBS) • 🇦🇪 UAE/GCC: Nexium / Losec (MOHAP) • 🇮🇳 India: Pan-D / Pan 40 / Omez 20 |
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| Same-Salt Commercial Brand Substitutes | Pan-DPantocid DSRPantodac DSRAciloc RDOmez-DSRRabicip-D |
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| Dosage Form & Route | Capsule (Hard Gelatin SR) (Topical Application) |
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| Manufacturer | Alkem Laboratories Ltd |
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| Branded MRP vs Jan Aushadhi Generic | MRP ₹195.00 vs Jan Aushadhi ₹18.00 • Save ₹177.00 (91% Off) |
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3. Clinical Indications, Mechanism of Action & Pharmacokinetics
Pan-D (Capsule (Hard Gelatin SR)) containing Pantoprazole Sodium (INN/USAN) 40mg + Domperidone (INN/BAN) 30mg Sustained Release is clinically indicated for the management and treatment of:
- Severe Acid Reflux (GERD) with Nausea: Targeted therapeutic efficacy via PPI Antacid + Prokinetic Antiemetic pathway modulation.
- Gastritis & Bloating: Targeted therapeutic efficacy via PPI Antacid + Prokinetic Antiemetic pathway modulation.
- Belching & Indigestion: Targeted therapeutic efficacy via PPI Antacid + Prokinetic Antiemetic pathway modulation.
- Peptic Ulcer: Targeted therapeutic efficacy via PPI Antacid + Prokinetic Antiemetic pathway modulation.
Mechanism of Action & Pharmacokinetics: Following administration as a capsule (hard gelatin sr), Pantoprazole Sodium (INN/USAN) 40mg + Domperidone (INN/BAN) 30mg Sustained Release undergoes calibrated systemic absorption and hepatic/renal clearance in accordance with WHO-GMP, USP, and Indian Pharmacopoeia (IP) dissolution and bioequivalence standards.
4. Standard Dosage Table, Administration & Storage Guidelines
Dosage & Administration Reference Table: Always follow your physician's prescription for Pan-D Capsule (Hard Gelatin SR) (ISMP safety normalized):
| Prescription Sig Code |
Administration Schedule |
Meal & Timing Guidance |
Clinical Patient Group |
| OD (Once Daily) |
1 unit (Capsule (Hard Gelatin SR)) every 24 hours |
30 minutes before breakfast on empty stomach |
Adults |
| BD / BID (Twice Daily) |
1 unit (Capsule (Hard Gelatin SR)) every 12 hours (Morning & Night) |
30 minutes before breakfast on empty stomach |
Adults |
| TDS / TID (Thrice Daily) |
1 unit (Capsule (Hard Gelatin SR)) every 8 hours (if prescribed) |
Maintain minimum 6–8 hour spacing |
As directed by registered physician |
Storage & Stability: Store Pan-D (Capsule (Hard Gelatin SR)) in a cool, dry place below 30°C (86°F) away from direct sunlight, heat, and moisture. Keep blister strips sealed until administration and out of reach of children.
8. Frequently Asked Questions (Pan-D Capsule (Hard Gelatin SR))
Q: What is Pan-D Capsule (Hard Gelatin SR) (Pantoprazole Sodium (INN/USAN) 40mg + Domperidone (INN/BAN) 30mg Sustained Release) used for?
Pan-D Capsule (Hard Gelatin SR) contains Pantoprazole Sodium (INN/USAN) 40mg + Domperidone (INN/BAN) 30mg Sustained Release and is manufactured by Alkem Laboratories Ltd. It is primarily indicated for Severe Acid Reflux (GERD) with Nausea, Gastritis & Bloating, Belching & Indigestion, Peptic Ulcer under the PPI Antacid + Prokinetic Antiemetic therapeutic class.
Q: Is a generic equivalent or Jan Aushadhi substitute available for Pan-D Capsule (Hard Gelatin SR)?
Yes, bioequivalent generic Pantoprazole Sodium (INN/USAN) 40mg + Domperidone (INN/BAN) 30mg Sustained Release (Capsule (Hard Gelatin SR)) is available globally ($3.24 USD NADAC / £2.52 UK NHS Tariff) and at PMBJP Jan Aushadhi Kendras in India for ₹18.00 per strip, saving 91% compared to branded MRP ₹195.00.
Q: What is the dosage instruction for Pan-D Capsule (Hard Gelatin SR)?
Common dosage frequencies for Pan-D (Capsule (Hard Gelatin SR)) are OD (once daily), BD/BID (twice daily), or TDS/TID (thrice daily) as prescribed by your physician. 30 minutes before breakfast on empty stomach
Q: Is Pan-D Capsule (Hard Gelatin SR) safe during pregnancy, breastfeeding, or with alcohol?
Pregnancy guidance: CAUTION — CONSULT DOCTOR (Use during pregnancy only if clearly needed and prescribed by an obstetrician after risk-benefit evaluation (FDA PLLR / TGA clinical guidance).) Alcohol guidance: AVOID (Avoid alcohol consumption during therapy to prevent additive hepatotoxicity, gastric irritation, or central nervous system sedation.)