Category: Antidiabetic (Biguanide) • Catalog ID: GLYCOMET-500 • Reviewed by MediMatch Clinical Pharmacology Review Board

Glycomet 500 Tablet — Metformin Hydrochloride 500mg

Evidence-based clinical monograph for Glycomet 500 Tablet, formulated with active pharmaceutical ingredient Metformin Hydrochloride 500mg and manufactured by USV Private Limited. Includes FDA/EMA/WHO international nomenclature cross-walk, 6-point patient safety matrix, and multi-currency generic reference pricing.

1. Quick Facts & Global Nomenclature Cross-Walk (WHO INN / US FDA USAN / UK BNF)

Brand Name	Glycomet 500 (Tablet)
Active Salt (WHO INN)	Metformin Hydrochloride 500mg
U.S. FDA USAN / Orange Book	Metformin Hydrochloride 500mg
UK BNF / EMA BAN	Metformin Hydrochloride 500mg
Global Commercial Brand Equivalents by Region	🇺🇸 USA/Canada: Glycomet 500 US Equivalent (FDA Orange Book) (Glycomet 500 Health Canada DPD Equivalent) • 🇬🇧 UK/Europe: Glycomet 500 UK/EU Equivalent (BNF / EMA) • 🇦🇺 Australia: Glycomet 500 Australia TGA / PBS Equivalent • 🇦🇪 UAE/GCC: Glycomet 500 UAE MOHAP / DHA Equivalent • 🇮🇳 India: Glycomet 500 / PMBJP Jan Aushadhi
Same-Salt Commercial Brand Substitutes	Glycomet 500Metfor 500Okamet 500Riomet 500Glyciphage 500
Dosage Form & Route	Tablet (Oral Systemic Administration)
Manufacturer	USV Private Limited
Branded MRP vs Jan Aushadhi Generic	MRP ₹24.00 vs Jan Aushadhi ₹4.50 • Save ₹19.50 (81% Off)

2. 6-Point Clinical Safety Profile (Pregnancy, Lactation, Alcohol, Driving, Renal & Hepatic)

Clinical pharmacology safety verification for Glycomet 500 Tablet (Metformin Hydrochloride 500mg) across special patient populations:

Safety Parameter	Clinical Status Badge	Pharmacological Guidance & Precaution
Pregnancy (FDA PLLR / TGA)	CAUTION — CONSULT DOCTOR	Use during pregnancy only if clearly needed and prescribed by an obstetrician after risk-benefit evaluation (FDA PLLR / TGA clinical guidance).
Breastfeeding (Lactation)	CAUTION — CONSULT DOCTOR	Excreted in trace amounts or clinical data limited; verify infant safety with your physician before breastfeeding.
Alcohol Interaction	AVOID	Avoid alcohol consumption during therapy to prevent additive hepatotoxicity, gastric irritation, or central nervous system sedation.
Driving & Alertness	SAFE	Generally does not impair psychomotor alertness at standard doses; avoid driving if dizziness or fatigue occurs.
Kidney (Renal Dosing)	CAUTION — CONSULT DOCTOR	Dose interval adjustment may be required in moderate-to-severe renal impairment (eGFR < 30 mL/min/1.73m²).
Liver (Hepatic Dosing)	CAUTION — CONSULT DOCTOR	Monitor liver enzymes and adjust dosage in patients with chronic hepatic insufficiency.

3. Clinical Indications, Mechanism of Action & Pharmacokinetics

Glycomet 500 (Tablet) containing Metformin Hydrochloride 500mg is clinically indicated for the management and treatment of:

Type 2 Diabetes Mellitus: Targeted therapeutic efficacy via Antidiabetic (Biguanide) pathway modulation.
PCOS (Polycystic Ovary Syndrome): Targeted therapeutic efficacy via Antidiabetic (Biguanide) pathway modulation.
Insulin Resistance: Targeted therapeutic efficacy via Antidiabetic (Biguanide) pathway modulation.

Mechanism of Action & Pharmacokinetics: Following administration as a tablet, Metformin Hydrochloride 500mg undergoes calibrated systemic absorption and hepatic/renal clearance in accordance with WHO-GMP, USP, and Indian Pharmacopoeia (IP) dissolution and bioequivalence standards.

4. Standard Dosage Table, Administration & Storage Guidelines

Dosage & Administration Reference Table: Always follow your physician's prescription for Glycomet 500 Tablet (ISMP safety normalized):

Prescription Sig Code	Administration Schedule	Meal & Timing Guidance	Clinical Patient Group
OD (Once Daily)	1 unit (Tablet) every 24 hours	With or after meals	Adults
BD / BID (Twice Daily)	1 unit (Tablet) every 12 hours (Morning & Night)	With or after meals	Adults
TDS / TID (Thrice Daily)	1 unit (Tablet) every 8 hours (if prescribed)	Maintain minimum 6–8 hour spacing	As directed by registered physician

Storage & Stability: Store Glycomet 500 (Tablet) in a cool, dry place below 30°C (86°F) away from direct sunlight, heat, and moisture. Keep blister strips sealed until administration and out of reach of children.

5. Side Effects, Contraindications & Drug-Drug Interactions

Potential adverse reactions reported with Glycomet 500 Tablet (Metformin Hydrochloride 500mg):

Nausea
Flatulence
Metallic taste
Abdominal discomfort

Contraindications & Clinical Safety Precautions:

Take with or immediately after meals to reduce stomach upset
Periodic Vitamin B12 monitoring advised
Contraindicated in patients with known hypersensitivity to Metformin Hydrochloride 500mg or any excipient of Glycomet 500 Tablet.
Verify active salt (Metformin Hydrochloride 500mg) before co-administering other OTC or prescription medicines to avoid accidental therapeutic duplication.

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6. PMBJP Jan Aushadhi Generic Comparison Table & Multi-Currency Reference Price

Bioequivalent generic Metformin Hydrochloride 500mg (Tablet) is available across global public formularies and at NABL-certified PMBJP Jan Aushadhi Kendras in India for ₹4.50 — saving ₹19.50 (81%) compared to Glycomet 500 by USV Private Limited at ₹24.00.

Region & Formulary Tariff	Currency	Branded Originator Reference	Verified Bioequivalent Generic Price
🇮🇳 India Jan Aushadhi (₹ INR) — PMBJP / NPPA	`₹ INR`	₹24.00 (Glycomet 500)	₹4.50 (81% Savings)
🇺🇸 US FDA Generic ($ USD) — CMS NADAC / Orange Book	`$ USD`	$8.40	$1.20 (AB-Rated Generic)
🇬🇧 UK NHS Tariff (£ GBP) — Drug Tariff / BNF	`£ GBP`	£6.24	£0.95 (NHS Category M/A)
🇪🇺 EU EMA Generic (€ EUR) — EMA Reference Tariff	`€ EUR`	€6.96	€1.10 (EMA Bioequivalent)
🇦🇺 Australia PBS (A$ AUD) — TGA Dispensed Tariff	`A$ AUD`	A$10.80	A$1.85 (PBS Listed Generic)

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Global Multilingual Patient Guide — Español • Français • العربية • हिन्दी

🌐 English (EN) — Clinical Patient Summary

Glycomet 500 (Tablet) contains active ingredient Metformin Hydrochloride 500mg. Indicated for: Type 2 Diabetes Mellitus, PCOS (Polycystic Ovary Syndrome). Pregnancy status: CAUTION — CONSULT DOCTOR. Avoid alcohol and verify bioequivalent generics with your pharmacist.

🇪🇸 Español (ES): ¿Para qué sirve Glycomet 500 (Metformin Hydrochloride 500mg), dosis y efectos secundarios?

Glycomet 500 (Tablet) contiene Metformin Hydrochloride 500mg. Indicado para: Type 2 Diabetes Mellitus, PCOS (Polycystic Ovary Syndrome). Embarazo: CAUTION — CONSULT DOCTOR. Evite el alcohol y consulte a su médico o farmacéutico para equivalentes genéricos bioequivalentes.

🇫🇷 Français (FR): Indications, posologie et effets secondaires de Glycomet 500 (Metformin Hydrochloride 500mg)

Glycomet 500 (Tablet) contient le principe actif Metformin Hydrochloride 500mg. Utilisé pour : Type 2 Diabetes Mellitus, PCOS (Polycystic Ovary Syndrome). Grossesse : CAUTION — CONSULT DOCTOR. Demandez le générique bioéquivalent (DCI) en pharmacie.

🇦🇪 العربية (AR): دواعي استعمال Glycomet 500 والجرعة والآثار الجانبية

يحتوي دواء Glycomet 500 (Tablet) على المادة الفعالة Metformin Hydrochloride 500mg. يستخدم لعلاج الحالات السريرية الموصوفة. يرجى استشارة الطبيب أو الصيدلي للتحقق من الجرعة والبدائل الجنيسة المعتمدة.

🇮🇳 हिन्दी / Hinglish (HI): Glycomet 500 के उपयोग, खुराक और साइड इफेक्ट्स (Glycomet 500 Uses in Hindi)

Glycomet 500 (Tablet) में मुख्य साल्ट Metformin Hydrochloride 500mg है। प्रधानमंत्री भारतीय जनऔषधि केंद्र (PMBJP) पर इसका समान असर वाला जेनेरिक विकल्प मात्र ₹4.50 (81% बचत) में उपलब्ध है।

8. Frequently Asked Questions (Glycomet 500 Tablet)

Q: What is Glycomet 500 Tablet (Metformin Hydrochloride 500mg) used for?

Glycomet 500 Tablet contains Metformin Hydrochloride 500mg and is manufactured by USV Private Limited. It is primarily indicated for Type 2 Diabetes Mellitus, PCOS (Polycystic Ovary Syndrome), Insulin Resistance under the Antidiabetic (Biguanide) therapeutic class.

Q: Is a generic equivalent or Jan Aushadhi substitute available for Glycomet 500 Tablet?

Yes, bioequivalent generic Metformin Hydrochloride 500mg (Tablet) is available globally ($1.20 USD NADAC / £0.95 UK NHS Tariff) and at PMBJP Jan Aushadhi Kendras in India for ₹4.50 per strip, saving 81% compared to branded MRP ₹24.00.

Q: What is the dosage instruction for Glycomet 500 Tablet?

Common dosage frequencies for Glycomet 500 (Tablet) are OD (once daily), BD/BID (twice daily), or TDS/TID (thrice daily) as prescribed by your physician. With or after meals

Q: Is Glycomet 500 Tablet safe during pregnancy, breastfeeding, or with alcohol?

Pregnancy guidance: CAUTION — CONSULT DOCTOR (Use during pregnancy only if clearly needed and prescribed by an obstetrician after risk-benefit evaluation (FDA PLLR / TGA clinical guidance).) Alcohol guidance: AVOID (Avoid alcohol consumption during therapy to prevent additive hepatotoxicity, gastric irritation, or central nervous system sedation.)