Category: Penicillin Antibiotic (Broad-Spectrum) • Catalog ID: AUGMENTIN-625 • Reviewed by MediMatch Clinical Pharmacology Review Board
Augmentin 625 Duo Tablet — Amoxicillin Trihydrate 500mg + Potassium Clavulanate 125mg
Evidence-based clinical monograph for Augmentin 625 Duo Tablet, formulated with active pharmaceutical ingredient Amoxicillin Trihydrate 500mg + Potassium Clavulanate 125mg and manufactured by GlaxoSmithKline Pharmaceuticals. Includes FDA/EMA/WHO international nomenclature cross-walk, 6-point patient safety matrix, and multi-currency generic reference pricing.
1. Quick Facts & Global Nomenclature Cross-Walk (WHO INN / US FDA USAN / UK BNF)
| Brand Name | Augmentin 625 Duo (Tablet) |
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| Active Salt (WHO INN) | Amoxicillin Trihydrate 500mg + Potassium Clavulanate 125mg |
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| U.S. FDA USAN / Orange Book | Amoxicillin Trihydrate 500mg + Potassium Clavulanate 125mg |
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| UK BNF / EMA BAN | Amoxicillin Trihydrate 500mg + Potassium Clavulanate 125mg |
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| Global Commercial Brand Equivalents by Region | 🇺🇸 USA/Canada: Augmentin 625 Duo US Equivalent (FDA Orange Book) (Augmentin 625 Duo Health Canada DPD Equivalent) • 🇬🇧 UK/Europe: Augmentin 625 Duo UK/EU Equivalent (BNF / EMA) • 🇦🇺 Australia: Augmentin 625 Duo Australia TGA / PBS Equivalent • 🇦🇪 UAE/GCC: Augmentin 625 Duo UAE MOHAP / DHA Equivalent • 🇮🇳 India: Augmentin 625 Duo / PMBJP Jan Aushadhi |
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| Same-Salt Commercial Brand Substitutes | Augmentin 625Moxikind-CV 625Clavam 625Advent 625Polyclav 625Mega-CV 625 |
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| Dosage Form & Route | Tablet (Oral Systemic Administration) |
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| Manufacturer | GlaxoSmithKline Pharmaceuticals |
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| Branded MRP vs Jan Aushadhi Generic | MRP ₹220.00 vs Jan Aushadhi ₹58.00 • Save ₹162.00 (74% Off) |
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3. Clinical Indications, Mechanism of Action & Pharmacokinetics
Augmentin 625 Duo (Tablet) containing Amoxicillin Trihydrate 500mg + Potassium Clavulanate 125mg is clinically indicated for the management and treatment of:
- Bacterial Throat Infections (Tonsillitis): Targeted therapeutic efficacy via Penicillin Antibiotic (Broad-Spectrum) pathway modulation.
- Sinusitis: Targeted therapeutic efficacy via Penicillin Antibiotic (Broad-Spectrum) pathway modulation.
- Pneumonia & Bronchitis: Targeted therapeutic efficacy via Penicillin Antibiotic (Broad-Spectrum) pathway modulation.
- Urinary Tract Infection (UTI): Targeted therapeutic efficacy via Penicillin Antibiotic (Broad-Spectrum) pathway modulation.
- Dental & Skin infections: Targeted therapeutic efficacy via Penicillin Antibiotic (Broad-Spectrum) pathway modulation.
Mechanism of Action & Pharmacokinetics: Following administration as a tablet, Amoxicillin Trihydrate 500mg + Potassium Clavulanate 125mg undergoes calibrated systemic absorption and hepatic/renal clearance in accordance with WHO-GMP, USP, and Indian Pharmacopoeia (IP) dissolution and bioequivalence standards.
4. Standard Dosage Table, Administration & Storage Guidelines
Dosage & Administration Reference Table: Always follow your physician's prescription for Augmentin 625 Duo Tablet (ISMP safety normalized):
| Prescription Sig Code |
Administration Schedule |
Meal & Timing Guidance |
Clinical Patient Group |
| OD (Once Daily) |
1 unit (Tablet) every 24 hours |
Take at start of meal |
Adults & Adolescents |
| BD / BID (Twice Daily) |
1 unit (Tablet) every 12 hours (Morning & Night) |
Take at start of meal |
Adults & Adolescents |
| TDS / TID (Thrice Daily) |
1 unit (Tablet) every 8 hours (if prescribed) |
Maintain minimum 6–8 hour spacing |
As directed by registered physician |
Storage & Stability: Store Augmentin 625 Duo (Tablet) in a cool, dry place below 30°C (86°F) away from direct sunlight, heat, and moisture. Keep blister strips sealed until administration and out of reach of children.
8. Frequently Asked Questions (Augmentin 625 Duo Tablet)
Q: What is Augmentin 625 Duo Tablet (Amoxicillin Trihydrate 500mg + Potassium Clavulanate 125mg) used for?
Augmentin 625 Duo Tablet contains Amoxicillin Trihydrate 500mg + Potassium Clavulanate 125mg and is manufactured by GlaxoSmithKline Pharmaceuticals. It is primarily indicated for Bacterial Throat Infections (Tonsillitis), Sinusitis, Pneumonia & Bronchitis, Urinary Tract Infection (UTI), Dental & Skin infections under the Penicillin Antibiotic (Broad-Spectrum) therapeutic class.
Q: Is a generic equivalent or Jan Aushadhi substitute available for Augmentin 625 Duo Tablet?
Yes, bioequivalent generic Amoxicillin Trihydrate 500mg + Potassium Clavulanate 125mg (Tablet) is available globally ($10.44 USD NADAC / £8.12 UK NHS Tariff) and at PMBJP Jan Aushadhi Kendras in India for ₹58.00 per strip, saving 74% compared to branded MRP ₹220.00.
Q: What is the dosage instruction for Augmentin 625 Duo Tablet?
Common dosage frequencies for Augmentin 625 Duo (Tablet) are OD (once daily), BD/BID (twice daily), or TDS/TID (thrice daily) as prescribed by your physician. Take at start of meal
Q: Is Augmentin 625 Duo Tablet safe during pregnancy, breastfeeding, or with alcohol?
Pregnancy guidance: CAUTION — CONSULT DOCTOR (Use during pregnancy only if clearly needed and prescribed by an obstetrician after risk-benefit evaluation (FDA PLLR / TGA clinical guidance).) Alcohol guidance: AVOID (Avoid alcohol consumption during therapy to prevent additive hepatotoxicity, gastric irritation, or central nervous system sedation.)